Medical Disclaimer: General information only — not medical advice. Always consult your oncologist, hepatologist, or qualified provider.

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The Liver Spot

Clinical Trials

HCC clinical trials currently enrolling patients. Bring the NCT number to your next oncology appointment to ask if you may be eligible.

NCT07811687Recruiting

Effect of Laparoscopic Hepatectomy Combined With Splenectomy on Hepatic Functional Reserve and Immune Function

Updated: Sep 10, 2026

View on ClinicalTrials.gov
NCT07814014Recruiting

Real-world Insight Into Systemic Therapies for HCC: Single-center Study

Updated: Sep 10, 2026

View on ClinicalTrials.gov
NCT07806292Recruiting

Anlotinib + Benmelstobart + HAIC in Unresectable HCC: A Phase II Study

Updated: Sep 8, 2026

View on ClinicalTrials.gov
NCT07808164Recruiting

ENPP1/cGAS (EG) and FAP Expression Profiles in Solid Tumors: An Immunohistochemical Study in a Vietnamese Cohort

Updated: Sep 8, 2026

View on ClinicalTrials.gov
NCT07801287Recruiting

Iparomlimab/Tuvonralimab Plus SBRT and Lenvatinib for Perioperative Treatment of Potentially Resectable Intermediate-Stage HCC

Updated: Sep 3, 2026

View on ClinicalTrials.gov
NCT07799922Recruiting

IRE After Targeted Immunotherapy in HCC With Portal Vein Tumor Thrombus

Updated: Sep 2, 2026

View on ClinicalTrials.gov
NCT07795437Recruiting

GPC3-Targeted PET Imaging of 18F-X12 in Hepatocellular Carcinoma

Updated: Sep 2, 2026

View on ClinicalTrials.gov
NCT07714538Recruiting

Breath Research Narrow Validation for Gastrointestinal Cancer Detection

Updated: Sep 11, 2026

View on ClinicalTrials.gov
NCT07677774Recruiting

GPC3-Targeted PET/CT in Hepatocellular Carcinoma

Updated: Sep 10, 2026

View on ClinicalTrials.gov
NCT07650773Recruiting

CHARM Hepatocellular Carcinoma MEA Study

Updated: Sep 3, 2026

View on ClinicalTrials.gov
NCT07636148Recruiting

Registry of Minimally Invasive Cancer Treatment Using Spectral Angio-CT Image Guidance

Updated: Sep 1, 2026

View on ClinicalTrials.gov
NCT07557251Recruiting

A Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of BRII-5395 in Combination With Sintilimab and Bevacizumab in Advanced Hepatitis B Virus Related Hepatocellular Carcinoma

Updated: Aug 31, 2026

View on ClinicalTrials.gov
NCT07463248Recruiting

PULSAR Combined With Fecal Microbiota Transplantation for Advanced Hepatocellular Carcinoma Progressing After First-Line Targeted-Immunotherapy

Updated: Sep 2, 2026

View on ClinicalTrials.gov
NCT07446257Recruiting

THIO and Cadonilimab in Resectable Hepatocellular Carcinoma

Updated: Sep 3, 2026

View on ClinicalTrials.gov
NCT07381660Recruiting

SBRT Versus Surgical Resection for Small HCC

Updated: Sep 1, 2026

View on ClinicalTrials.gov
NCT07284121Recruiting

A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice

Updated: Sep 11, 2026

View on ClinicalTrials.gov
NCT07272083Recruiting

New Diagnostic Criteria in the Evaluation Response to Ablation Treatment of Hepatocellular Carcinoma Nodules

Updated: Sep 9, 2026

View on ClinicalTrials.gov
NCT07062055Recruiting

BITS-TO-HCC Study: HAIC+Iparomlimab/Tuvonralimab + Bevacizumab + Surgery/SBRT for BCLC-C HCC With PVTT and/or Oligometastases

Updated: Sep 4, 2026

View on ClinicalTrials.gov
NCT06999837Recruiting

[68Ga]Ga-PSMA PET/CT in Hepatocellular Carcinoma: Impact of Multiparametric Dynamic Whole-body Imaging and Kinetic Modeling.

Updated: Sep 3, 2026

View on ClinicalTrials.gov
NCT06995898Recruiting

The Vanguard Study: Testing a New Way to Screen for Cancer

Updated: Sep 2, 2026

View on ClinicalTrials.gov
NCT06921785Recruiting

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

Updated: Sep 3, 2026

View on ClinicalTrials.gov
NCT06811116Recruiting

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

Updated: Sep 3, 2026

View on ClinicalTrials.gov
NCT06638502Recruiting

Safety of HRX215 in Patients After Minor and Major Liver Resection

Updated: Sep 1, 2026

View on ClinicalTrials.gov
NCT06621472Recruiting

Retrolaminar Block Versus Subcostal Transversus Abdominis Plane Block in Liver Resection Surgery

Updated: Sep 1, 2026

View on ClinicalTrials.gov
NCT06563947Recruiting

Oral Fecal Microbiota Transplantation in Advanced Hepatocellular Carcinoma After Progression on ICI-TKI Therapy

Updated: Sep 10, 2026

View on ClinicalTrials.gov
NCT06526338Recruiting

Adjuvant IP-001 Treatment for HCC Patients Following Surgical Resection and Ablation or Ablation Alone

Updated: Sep 4, 2026

View on ClinicalTrials.gov
NCT06486454Recruiting

Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)

Updated: Sep 11, 2026

View on ClinicalTrials.gov
NCT06427941Recruiting

A Phase 1/2 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors

Updated: Sep 8, 2026

View on ClinicalTrials.gov
NCT06309485Recruiting

Phase 2 Study of WGI-0301 for Advanced HCC

Updated: Sep 11, 2026

View on ClinicalTrials.gov
NCT06294548Recruiting

A Study of Valemetostat Tosylate (DS-3201b) With Atezolizumab and Bevacizumab in HCC

Updated: Sep 1, 2026

View on ClinicalTrials.gov
NCT06252753Recruiting

Observational Study Protocol: LIVER-R

Updated: Sep 8, 2026

View on ClinicalTrials.gov
NCT06066138Recruiting

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

Updated: Sep 8, 2026

View on ClinicalTrials.gov
NCT05497531Recruiting

Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

Updated: Aug 31, 2026

View on ClinicalTrials.gov
NCT05304481Recruiting

Efficacy and Safety of Activated T Lymphocytes (ATL) in Hepatocellular Carcinoma

Updated: Sep 1, 2026

View on ClinicalTrials.gov
NCT04864054Recruiting

GPC3-Targeted T-Cell Therapy (ECT204) in Adults With Advanced HCC

Updated: Sep 10, 2026

View on ClinicalTrials.gov