Medical Disclaimer: General information only — not medical advice. Always consult your oncologist, hepatologist, or qualified provider.

Emergency?
The Liver Spot

Clinical Trials

HCC clinical trials currently enrolling patients. Bring the NCT number to your next oncology appointment to ask if you may be eligible.

NCT07717437Recruiting

DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.

Updated: Jul 21, 2026

View on ClinicalTrials.gov
NCT07704489Recruiting

San Raffaele Registry on Liver Cancer

Updated: Jul 15, 2026

View on ClinicalTrials.gov
NCT07657897Recruiting

The Impact of Anaesthesia and Sedation on Inflammation and NETosis in Hepatocellular Carcinoma Ablation

Updated: Jul 21, 2026

View on ClinicalTrials.gov
NCT07607769Recruiting

MONTEROSA - Italian Multicenter Observational Study to Evaluate Time to Clinical Hepatic Decompensation, Quality of Life, Effectiveness, and Safety of Tremelimumab Plus Durvalumab in Patients With Advanced or Unresectable Hepatocellular Carcinoma Who Have Received no Prior Systemic Treatment.

Updated: Jul 27, 2026

View on ClinicalTrials.gov
NCT07521852Recruiting

A Phase IIa, Single-arm, Open-label Clinical Study to Evaluate the Efficacy, Safety and PK of CVM-1118 in Combination With Sintilimab and TACE in Participants With Incurable/Non-metastatic HCC

Updated: Jul 23, 2026

View on ClinicalTrials.gov
NCT07479485Recruiting

MRG006A Combination Therapy for Advanced Hepatocellular Carcinoma (Phase I/II)

Updated: Jul 28, 2026

View on ClinicalTrials.gov
NCT07419841Recruiting

A Phase 1 Study of the Safety and Tolerability of CTX-10726

Updated: Jul 20, 2026

View on ClinicalTrials.gov
NCT07377487Recruiting

TheraSphere Japan Pre-Market Study

Updated: Jul 23, 2026

View on ClinicalTrials.gov
NCT07291076Recruiting

A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)

Updated: Jul 23, 2026

View on ClinicalTrials.gov
NCT07284121Recruiting

A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice

Updated: Jul 17, 2026

View on ClinicalTrials.gov
NCT07227012Recruiting

Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.

Updated: Jul 22, 2026

View on ClinicalTrials.gov
NCT07219459Recruiting

Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure

Updated: Jul 21, 2026

View on ClinicalTrials.gov
NCT07059494Recruiting

Atezolizumab and Bevacizumab in Combination With Y^90 Radioembolization in HCC for Liver Transplant

Updated: Jul 28, 2026

View on ClinicalTrials.gov
NCT07010497Recruiting

A Prospective Study to Evaluate the Safety and Efficacy of the Combination Therapy of Irpagratinib, Atezolizumab, and Bevacizumab in Patients With Hepatocellular Carcinoma

Updated: Jul 15, 2026

View on ClinicalTrials.gov
NCT06990659Recruiting

Outpatient Versus Inpatient Care Pathway for Intra-arterial Treatment of Primary Liver Cancer (CHOC)

Updated: Jul 17, 2026

View on ClinicalTrials.gov
NCT06921785Recruiting

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

Updated: Jul 14, 2026

View on ClinicalTrials.gov
NCT06910657Recruiting

IDOV-Immune for Advanced Solid Tumors

Updated: Jul 24, 2026

View on ClinicalTrials.gov
NCT06880523Recruiting

STRIDE (Durvalumab + Tremelimumab) With Lenvatinib vs STRIDE Alone in Unresectable Hepatocellular Carcinoma

Updated: Jul 14, 2026

View on ClinicalTrials.gov
NCT06811116Recruiting

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

Updated: Jul 24, 2026

View on ClinicalTrials.gov
NCT06796803Recruiting

Camrelizumab Combined With Rivoceranib and Hepatic Arterial Infusion Chemotherapy (HAIC) as Conversion Therapy for Potentially Resectable Hepatocellular Carcinoma(HCC)

Updated: Jul 17, 2026

View on ClinicalTrials.gov
NCT06796114Recruiting

Identification of Innovative Biomarkers to Predict Outcomes in Hepatocellular Carcinoma Treated With Tremelimumab and Durvalumab

Updated: Jul 23, 2026

View on ClinicalTrials.gov
NCT06764316Recruiting

A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer

Updated: Jul 15, 2026

View on ClinicalTrials.gov
NCT06478719Recruiting

To Evaluate Safety and Efficacy of FB-1603 in Hepatocellular Carcinoma Patient Receiving Transarterial Chemoembolization

Updated: Jul 15, 2026

View on ClinicalTrials.gov
NCT06252753Recruiting

Observational Study Protocol: LIVER-R

Updated: Jul 17, 2026

View on ClinicalTrials.gov
NCT06066138Recruiting

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

Updated: Jul 28, 2026

View on ClinicalTrials.gov
NCT05919264Recruiting

FOG-001 in Locally Advanced or Metastatic Solid Tumors

Updated: Jul 23, 2026

View on ClinicalTrials.gov
NCT05705492Recruiting

Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer

Updated: Jul 16, 2026

View on ClinicalTrials.gov
NCT05669339Recruiting

AD HOC Trial: Artificial Intelligence-Based Drug Dosing In Hepatocellular Carcinoma

Updated: Jul 14, 2026

View on ClinicalTrials.gov
NCT05503797Recruiting

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

Updated: Jul 27, 2026

View on ClinicalTrials.gov
NCT05248581Recruiting

Living Donor Liver Transplant for Unresectable Colorectal Liver Metastases

Updated: Jul 20, 2026

View on ClinicalTrials.gov
NCT05208762Recruiting

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

Updated: Jul 22, 2026

View on ClinicalTrials.gov
NCT05092373Recruiting

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

Updated: Jul 16, 2026

View on ClinicalTrials.gov