Medical Disclaimer: General information only — not medical advice. Always consult your oncologist, hepatologist, or qualified provider.

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The Liver Spot

Clinical Trials

HCC clinical trials currently enrolling patients. Bring the NCT number to your next oncology appointment to ask if you may be eligible.

NCT07884877Recruiting

PULSAR Radiotherapy Combined With Immunotherapy for High-Risk Advanced Liver Cancer

Updated: Oct 21, 2026

View on ClinicalTrials.gov
NCT07808164Recruiting

ENPP1/cGAS (EG) and FAP Expression Profiles in Solid Tumors: An Immunohistochemical Study in a Vietnamese Cohort

Updated: Oct 26, 2026

View on ClinicalTrials.gov
NCT07760012Recruiting

68Ga-SorB PET/CT Imaging in Patients With Solid Tumors

Updated: Oct 15, 2026

View on ClinicalTrials.gov
NCT07749586Recruiting

A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors

Updated: Oct 13, 2026

View on ClinicalTrials.gov
NCT07714538Recruiting

Breath Research Narrow Validation for Gastrointestinal Cancer Detection

Updated: Oct 22, 2026

View on ClinicalTrials.gov
NCT07650773Recruiting

CHARM Hepatocellular Carcinoma MEA Study

Updated: Oct 14, 2026

View on ClinicalTrials.gov
NCT07590336Recruiting

68Ga-NYM207 PET/CT Imaging in Hepatocellular Carcinoma

Updated: Oct 21, 2026

View on ClinicalTrials.gov
NCT07487662Recruiting

TACE or Ablation Combined With Sintilimab and Ipilimumab N01 as Neoadjuvant Therapy for Resectable Hepatocellular Carcinoma With Intermediate-High Recurrence Risk

Updated: Oct 27, 2026

View on ClinicalTrials.gov
NCT07419841Recruiting

A Phase 1 Study of the Safety and Tolerability of CTX-10726

Updated: Oct 23, 2026

View on ClinicalTrials.gov
NCT07405086Recruiting

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

Updated: Oct 13, 2026

View on ClinicalTrials.gov
NCT07377487Recruiting

TheraSphere Japan Pre-Market Study

Updated: Oct 21, 2026

View on ClinicalTrials.gov
NCT07291076Recruiting

A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination With Ipilimumab in Participants With First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC) (ROSETTA HCC-206)

Updated: Oct 23, 2026

View on ClinicalTrials.gov
NCT07197554Recruiting

A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

Updated: Oct 27, 2026

View on ClinicalTrials.gov
NCT07062055Recruiting

BITS-TO-HCC Study: HAIC+Iparomlimab/Tuvonralimab + Bevacizumab + Surgery/SBRT for BCLC-C HCC With PVTT and/or Oligometastases

Updated: Oct 15, 2026

View on ClinicalTrials.gov
NCT07053072Recruiting

PD-1 mRNA LNP Vaccine for Advanced Primary Hepatocellular Carcinoma.

Updated: Oct 13, 2026

View on ClinicalTrials.gov
NCT07042919Recruiting

Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Liver Cancer

Updated: Oct 23, 2026

View on ClinicalTrials.gov
NCT07036874Recruiting

Non-invasive Assessment for Outcome Prediction in Patients With Hepatocellular Carcinoma

Updated: Oct 20, 2026

View on ClinicalTrials.gov
NCT06921785Recruiting

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

Updated: Oct 13, 2026

View on ClinicalTrials.gov
NCT06915753Recruiting

Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

Updated: Oct 14, 2026

View on ClinicalTrials.gov
NCT06841172Recruiting

Continuation of First-line Therapy With Radiotherapy Versus Early Switch to Second-line Therapy in Oligoprogressive HCC

Updated: Oct 13, 2026

View on ClinicalTrials.gov
NCT06811116Recruiting

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

Updated: Oct 26, 2026

View on ClinicalTrials.gov
NCT06795022Recruiting

First in Human Study to Evaluate AZD9793 in Participants With Advanced or Metastatic Solid Tumours

Updated: Oct 14, 2026

View on ClinicalTrials.gov
NCT06789757Recruiting

The Study of Atezolizumab, Bevacizumab and Memantine in Patients With Hepatocellular Carcinoma (HCC)

Updated: Oct 16, 2026

View on ClinicalTrials.gov
NCT06764316Recruiting

A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer

Updated: Oct 21, 2026

View on ClinicalTrials.gov
NCT06644430Recruiting

Ablation of Pulmonary Oligometastasis Combined With System for Advanced Hepatocellular Carcinoma

Updated: Oct 23, 2026

View on ClinicalTrials.gov
NCT06600321Recruiting

A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

Updated: Oct 27, 2026

View on ClinicalTrials.gov
NCT06582017Recruiting

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

Updated: Oct 20, 2026

View on ClinicalTrials.gov
NCT06330064Recruiting

A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)

Updated: Oct 26, 2026

View on ClinicalTrials.gov
NCT06265272Recruiting

Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis

Updated: Oct 14, 2026

View on ClinicalTrials.gov
NCT06239194Recruiting

Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

Updated: Oct 15, 2026

View on ClinicalTrials.gov
NCT06084481Recruiting

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

Updated: Oct 14, 2026

View on ClinicalTrials.gov
NCT06066138Recruiting

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

Updated: Oct 16, 2026

View on ClinicalTrials.gov
NCT05914116Recruiting

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

Updated: Oct 21, 2026

View on ClinicalTrials.gov
NCT05901519Recruiting

A Pilot Study of Liver Protection Using Prednisone for Patients Receiving Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

Updated: Oct 15, 2026

View on ClinicalTrials.gov
NCT05440708Recruiting

A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma

Updated: Oct 22, 2026

View on ClinicalTrials.gov
NCT05003895Recruiting

GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Solid Tumor Malignancies

Updated: Oct 16, 2026

View on ClinicalTrials.gov
NCT04933435Recruiting

Interventional Radiology Liver Directed Therapies and Hypofractionated Image-Guided Radiation Therapy in Veteran and Non-Veteran, Non-surgical Hepatocellular Carcinoma Patients

Updated: Oct 22, 2026

View on ClinicalTrials.gov
NCT04792463Recruiting

Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

Updated: Oct 16, 2026

View on ClinicalTrials.gov
NCT04587739Recruiting

Neoadjuvant Hypofractionated Stereotactic Body Radiation Therapy Prior to Surgery for Hepatocellular Carcinoma: a Feasibility Study.

Updated: Oct 26, 2026

View on ClinicalTrials.gov
NCT04472767Recruiting

Cabozantinib Combined With Ipilimumab/Nivolumab and TACE in Patients With Hepatocellular Carcinoma

Updated: Oct 26, 2026

View on ClinicalTrials.gov
NCT03432806Recruiting

A Study of Imaging, Blood, and Tissue Samples to Guide Treatment of Colon Cancer and Related Liver Tumors

Updated: Oct 13, 2026

View on ClinicalTrials.gov